G(mega) Jacomex VS cell culture isolator Comecer

G(Mega) by Jacomex is a large-volume, fully modular glove box designed for industrial applications requiring a controlled atmosphere. It facilitates the integration of complex processes, robots, and specific applications, offering a tailor-made solution for demanding production environments.

The Cell Culture Isolator by Comecer is a cutting-edge containment system specifically designed for regenerative medicine and tissue engineering applications. It provides a sterile and controlled Class A (ISO 5) environment for handling cells and tissues, ensuring maximum protection against cross-contamination. This system effectively replaces traditional cleanrooms by creating a rigid physical barrier between the operator and biological processes, which is essential for the production of Advanced Therapy Medicinal Products (ATMPs).

• Additive manufacturing: metal 3D printing under inert atmosphere.
• Aerospace: welding and assembly of sensitive components.
• Robot integration: automation of processes in controlled environments.
• Machine and process protection: operations under reducing atmospheres.
• Enclosure of installations: assembly lines under anti-oxidizing and/or low-humidity atmospheres.

G(Mega)  Jacomex is the ideal solution for industries requiring a large-capacity, adaptable, and high-performance containment enclosure. Its modular design and customizable equipment ensure optimal integration into various industrial processes, providing a reliable and secure controlled atmosphere.

This isolator is primarily used in the following fields:

• Regenerative Medicine: Expansion and manipulation of stem cells intended for human cell therapies.
• Tissue Engineering: Development of complex biological tissues within a sterile environment.
• ATMP Production: Manufacturing of advanced therapy medicinal products under strict GMP compliance.
• Sensitive Cell Culture: Clinical research requiring absolute protection against atmospheric and human contaminants.

• Modular design: allowing volumes up to 150 m³.
• Facilitated integration: suitable for process robots and machines.
• Controlled atmosphere: operation under positive or negative pressure with inert gas.
• Purification systems: compatible with P(sys)-IV units for efficient removal of humidity and oxygen.
• Additional equipment: oxygen sensors, copper catalysts, HEPA filters, gloves, etc.
• Transfer airlocks: standard or custom-designed for large parts and tools.

The isolator features a modular design to adapt to the specific needs of each laboratory. It is constructed from AISI 316L stainless steel with rounded corners to facilitate cleaning. The system maintains unidirectional laminar flow across the entire work area, ensuring constant air purity. A key feature of this equipment is its integrated Vaporized Hydrogen Peroxide (VPHP) decontamination system, allowing for fast and automated sterilization of internal surfaces.

Operation is managed through an intuitive touch screen for real-time monitoring of pressure, humidity, temperature, and gas concentrations ($CO_2$, $O_2$). The isolator can integrate various equipment such as incubators, centrifuges, or microscopes while maintaining the integrity of the containment barrier. Rapid Transfer Ports (RTP) and decontamination airlocks allow for the introduction or removal of sterile materials without compromising the internal Class A environment.