Automated Cell Culture Line on Roller Bottle

Roller bottle cell culture in the pharmaceutical and medical sectors can be automated to optimise operational efficiency and improve working conditions for employees.

Our partner can design and manufacture an automated roller bottle cell culture line. The solution can be customised to suit your needs and the specific features of your manufacturing process.

Cell Culture in Roller Bottles

Roller bottle cell culture is a pharmaceutical and medical process that involves growing cells in a dedicated container. A roller bottle can be fitted with axial folds to increase the surface area for cell growth. It can also be fitted with circumferential ribs used to solidify the walls of the bottle. Rolling bottles are cylindrical in shape. They are designed to rotate around their axes. Their rotation ensures that the entire inside of the bottle is wetted to promote cell culture.

Cell culture in rolling bottles is useful in the manufacture of certain pharmaceutical products, particularly in animal health. It is used to grow large quantities of cells, from which the secreted substances are recovered and used in various processes.

Cell culture in roller bottles is subject to strict conditions. The conditions inside the roller bottles must be controlled: pressure, temperature, pH, humidity, etc. The bottles also need to be handled regularly and precisely to ensure that the cells develop correctly. With this in mind, it is useful to have an automated cell culture line on a roller bottle. This automates bottle handling, loading and unloading operations.

Why Automate in-line Cell Culture?

Performing cell culture tasks manually is possible if very few roller bottles are used. Difficulties arise in the pharmaceutical industry, where cell culture is carried out on a large scale. The culture parameters must be set correctly to ensure the success of the process, such as the speed, duration and direction of rotation of the containers.

To facilitate the handling of the Roller Bottles, the integration of the automated cell culture line is the solution. It offers several advantages. It is used to optimise cell development conditions. It is equipped with a robotic solution whose role is to handle, load and unload the bottles. The line is also equipped with an LCD touch screen for setting culture parameters, such as the volume of products to be dosed.

The automated cell culture line on roller bottle ensures that processes comply with Good Manufacturing Practice (GMP). The chassis is made of stainless steel, so there is no risk of oxidation over time or decontamination. A built-in battery ensures the continuous operation of the bottles on the production line. The battery has an autonomy of 2 hours. Depending on your needs, our partners can equip your automated cell culture line with an RFID system to optimise production monitoring and traceability.

Manufacturer of Automated Cell Culture Lines

Our industrial partners are a manufacturer of automated cell culture lines on rolling bottles. By making us your partner, we can provide you an quotation for a tailor-made solution. Their engineers will design a solution that takes into account the specific features of your roller bottle cell culture process. You can, for example, choose the size of Roller Bottle (generally between 6 and 16 per line), specify the characteristics of the trolley and fit it with RFID tags. The automated roller bottle cell culture line designed complies with pharmaceutical manufacturing standards. It also withstands the usual incubation conditions (T°, %Hr).

Get more information about our product by contacting our technical experts.